• 2517 Citations
  • 23 h-Index
1991 …2019
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Research Output 1991 2019

  • 2517 Citations
  • 23 h-Index
  • 94 Article
  • 11 Review article
  • 6 Conference contribution
  • 1 Chapter
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Article
2019

Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase

Giovannoni, M. P., Cantini, N., Crocetti, L., Guerrini, G., Iacovone, A., Schepetkin, I. A., Vergelli, C., Khlebnikov, A. I. & Quinn, M. T., 1 Jan 2019, In : Drug Development Research.

Research output: Contribution to journalArticle

Secretory Proteinase Inhibitory Proteins
Leukocyte Elastase
Multifunctional Enzymes
pyrrolo(2, 3-b)pyridine
Respiratory System
1 Citation (Scopus)

Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70

Khlebnikov, A. I., Schepetkin, I. A., Kishkentaeva, A. S., Shaimerdenova, Z. R., Atazhanova, G. A., Adekenov, S. M., Kirpotina, L. N. & Quinn, M. T., 19 Jan 2019, In : Molecules (Basel, Switzerland). 24, 2

Research output: Contribution to journalArticle

glutathione
Molecular modeling
Sesquiterpenes
tyrosine
Lactones
1 Citation (Scopus)

Neutrophil immunomodulatory activity of natural organosulfur compounds

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Balasubramanian, N. & Quinn, M. T., 1 Jan 2019, In : Molecules. 24, 9, 1809.

Research output: Contribution to journalArticle

Open Access
neutrophils
Volatile Oils
Neutrophils
Reactive Oxygen Species
Phosphatidylinositol 3-Kinase
1 Citation (Scopus)

Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats

Plotnikov, M. B., Chernysheva, G. A., Aliev, O. I., Smol'iakova, V. I., Fomina, T. I., Osipenko, A. N., Rydchenko, V. S., Anfinogenova, Y. J., Khlebnikov, A. I., Schepetkin, I. A. & Atochin, D. N., 1 Jan 2019, In : Molecules. 24, 9, 1722.

Research output: Contribution to journalArticle

Open Access
ischemia
Brain Ischemia
inhibitors
rats
Rats

Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25

Schepetkin, I. A., Karpenko, A. S., Khlebnikov, A. I., Shibinska, M. O., Levandovskiy, I. A., Kirpotina, L. N., Danilenko, N. V. & Quinn, M. T., 1 Dec 2019, In : European Journal of Medicinal Chemistry. 183, 111719.

Research output: Contribution to journalArticle

MAP Kinase Kinase 7
Molecular modeling
Cell Cycle
Naphthoquinones
Cytotoxicity
1 Citation (Scopus)

Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors

Schepetkin, I. A., Khlebnikov, A. I., Potapov, A. S., Kovrizhina, A. R., Matveevskaya, V. V., Belyanin, M. L., Atochin, D. N., Zanoza, S. O., Gaidarzhy, N. M., Lyakhov, S. A., Kirpotina, L. N. & Quinn, M. T., 1 Jan 2019, In : European Journal of Medicinal Chemistry. 161, p. 179-191 13 p.

Research output: Contribution to journalArticle

Quinoxalines
Molecular modeling
Oximes
JNK Mitogen-Activated Protein Kinases
Derivatives

Synthesis, Structure, and Anti-Inflammatory Activity of Functionally Substituted Chalcones and Their Derivatives

Nurkenov, O. A., Ibraev, M. K., Schepetkin, I. A., Khlebnikov, A. I., Seilkhanov, T. M., Arinova, A. E. & Isabaeva, M. B., 1 Jul 2019, In : Russian Journal of General Chemistry. 89, 7, p. 1360-1367 8 p.

Research output: Contribution to journalArticle

Chalcones
Anti-Inflammatory Agents
Derivatives
Nuclear magnetic resonance spectroscopy
Experiments
2018
3 Citations (Scopus)

1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors

Crocetti, L., Giovannoni, M. P., Schepetkin, I. A., Quinn, M. T., Khlebnikov, A. I., Cantini, N., Guerrini, G., Iacovone, A., Teodori, E. & Vergelli, C., 15 Nov 2018, In : Bioorganic and Medicinal Chemistry. 26, 21, p. 5583-5595 13 p.

Research output: Contribution to journalArticle

Secretory Proteinase Inhibitory Proteins
Leukocyte Elastase
Scaffolds
Indazoles
Oxadiazoles
1 Citation (Scopus)
JNK Mitogen-Activated Protein Kinases
Reperfusion Injury
Brain Injuries
Pharmacology
Brain
8 Citations (Scopus)

Physicochemical characterization and antioxidant activity of humic acids isolated from peat of various origins

Zykova, M. V., Schepetkin, I. A., Belousov, M. V., Krivoshchekov, S. V., Logvinova, L. A., Bratishko, K. A., Yusubov, M. S., Romanenko, S. V. & Quinn, M. T., 1 Jan 2018, In : Molecules. 23, 4, 753.

Research output: Contribution to journalArticle

Open Access
peat
Humic Substances
Peat
antioxidants
Soil
2017
4 Citations (Scopus)

4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones as N-formyl peptide receptor 1 (FPR1) antagonists

Kirpotina, L. N., Schepetkin, I. A., Khlebnikov, A. I., Ruban, O. I., Ge, Y., Ye, R. D., Kominsky, D. J. & Quinn, M. T., 2017, (Accepted/In press) In : Biochemical Pharmacology. 142, p. 120-132 13 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
HL-60 Cells
Pyrroles
Neutrophils
Trp-Lys-Tyr-Met-Val-Met
5 Citations (Scopus)

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Özek, G., Schepetkin, I. A., Utegenova, G. A., Kirpotina, L. N., Andrei, S. R., Özek, T., Başer, K. H. C., Abidkulova, K. T., Kushnarenko, S. V., Khlebnikov, A. I., Damron, D. S. & Quinn, M. T., 1 Jun 2017, In : Journal of Leukocyte Biology. 101, 6, p. 1361-1371 11 p.

Research output: Contribution to journalArticle

Ferula
Volatile Oils
Phagocytes
Disulfides
Neutrophils
9 Citations (Scopus)

Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors

Vergelli, C., Schepetkin, I. A., Crocetti, L., Iacovone, A., Giovannoni, M. P., Guerrini, G., Khlebnikov, A. I., Ciattini, S., Ciciani, G. & Quinn, M. T., 1 Jan 2017, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 32, 1, p. 821-831 11 p.

Research output: Contribution to journalArticle

Secretory Proteinase Inhibitory Proteins
Leukocyte Elastase
Carbon Monoxide
Lung Diseases
Inhibitory Concentration 50
tracers
positrons
tomography
molecular biology
imaging techniques
1 Citation (Scopus)

Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide

Nurkenov, O. A., Satpaeva, Z. B., Schepetkin, I. A., Khlebnikov, A. I., Turdybekov, K. M., Seilkhanov, T. M. & Fazylov, S. D., 1 Oct 2017, In : Russian Journal of General Chemistry. 87, 10, p. 2299-2306 8 p.

Research output: Contribution to journalArticle

Hydroxybenzoates
Hydrazones
Bioactivity
Cathepsins
Molecules

Synthesis of new hydrazones based on o- and p-hydroxybenzohydrazides

Nurkenov, O. A., Satpaeva, Z. B., Shchepetkin, I. A., Fazylov, S. D., Seilkhanov, T. M. & Akhmetova, S. B., 1 Aug 2017, In : Russian Journal of General Chemistry. 87, 8, p. 1707-1710 4 p.

Research output: Contribution to journalArticle

Hydrazones
Cathepsin E
Aldehydes
2016
6 Citations (Scopus)

2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists

Vergelli, C., Schepetkin, I. A., Ciciani, G., Cilibrizzi, A., Crocetti, L., Giovannoni, M. P., Guerrini, G., Iacovone, A., Kirpotina, L. N., Khlebnikov, A. I., Ye, R. D. & Quinn, M. T., 1 Jun 2016, In : Bioorganic and Medicinal Chemistry. 24, 11, p. 2530-2543 14 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Pathology
G-Protein-Coupled Receptors
Protein Isoforms
Chemical activation
14 Citations (Scopus)

A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice

Atochin, D. N., Shchepetkin, I. A., Khlebnikov, A. I., Seledtsov, V. I., Swanson, H., Quinn, M. T. & Huang, P. L., 8 Apr 2016, In : Neuroscience Letters. 618, p. 45-49 5 p.

Research output: Contribution to journalArticle

Oximes
JNK Mitogen-Activated Protein Kinases
Reperfusion Injury
Brain Ischemia
Nitric Oxide
13 Citations (Scopus)

Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives

Schepetkin, I. A., Khlebnikov, A. I., Kirpotina, L. N. & Quinn, M. T., 1 Aug 2016, In : International Immunopharmacology. 37, p. 43-58 16 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Biological Products
Neutrophils
HL-60 Cells
human FPR1 protein
19 Citations (Scopus)

Cinnoline derivatives as human neutrophil elastase inhibitors

Giovannoni, M. P., Schepetkin, I. A., Crocetti, L., Ciciani, G., Cilibrizzi, A., Guerrini, G., Khlebnikov, A. I., Quinn, M. T. & Vergelli, C., 3 Jul 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 4, p. 628-639 12 p.

Research output: Contribution to journalArticle

Secretory Proteinase Inhibitory Proteins
Leukocyte Elastase
Structure-Activity Relationship
cinnoline
Human Activities
10 Citations (Scopus)

Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents

Schepetkin, I. A., Kushnarenko, S. V., Özek, G., Kirpotina, L. N., Sinharoy, P., Utegenova, G. A., Abidkulova, K. T., Özek, T., Başer, K. H. C., Kovrizhina, A. R., Khlebnikov, A. I., Damron, D. S. & Quinn, M. T., 28 Sep 2016, In : Journal of Agricultural and Food Chemistry. 64, 38, p. 7156-7170 15 p.

Research output: Contribution to journalArticle

Ferula
Volatile Oils
neutrophils
essential oils
sabinene
3 Citations (Scopus)

Synthesis and Cytotoxicity of bis(pyrazol-1-yl)-Alkane Derivatives with Polymethylene Linkers and Related Mono- and Dipyrazolium Salts

Zatonskaya, L. V., Schepetkin, I. A., Petrenko, T. V., Ogorodnikov, V. D., Khlebnikov, A. I. & Potapov, A. S., 1 Jun 2016, In : Chemistry of Heterocyclic Compounds. 52, 6, p. 388-401 14 p.

Research output: Contribution to journalArticle

Alkanes
Cytotoxicity
Salts
Derivatives
Alkylation
6 Citations (Scopus)

Synthesis and Pharmacological Evaluation of Indole Derivatives as Deaza Analogues of Potent Human Neutrophil Elastase Inhibitors

Crocetti, L., Schepetkin, I. A., Ciciani, G., Giovannoni, M. P., Guerrini, G., Iacovone, A., Khlebnikov, A. I., Kirpotina, L. N., Quinn, M. T. & Vergelli, C., 2016, (Accepted/In press) In : Drug Development Research.

Research output: Contribution to journalArticle

Secretory Proteinase Inhibitory Proteins
Indazoles
Pharmacology
Inhibitory Concentration 50
Research
7 Citations (Scopus)

Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed)

Schepetkin, I. A., Ramstead, A. G., Kirpotina, L. N., Voyich, J. M., Jutila, M. A. & Quinn, M. T., 2016, (Accepted/In press) In : Phytotherapy Research.

Research output: Contribution to journalArticle

Bassia scoparia
Epilobium
Polyphenols
Therapeutic Uses
Flavonoids
2015
5 Citations (Scopus)

Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B

Ramstead, A. G., Schepetkin, I. A., Todd, K., Loeffelholz, J., Berardinelli, J. G., Quinn, M. T. & Jutila, M. A., 1 Jun 2015, In : International Immunopharmacology. 26, 2, p. 367-377 11 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Polyphenols
Fetal Blood
Cytokines
oenothein B
17 Citations (Scopus)

Anti-inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun n-terminal kinase inhibitor

Schepetkin, I. A., Kirpotina, L. N., Hammaker, D., Kochetkova, I., Khlebnikov, A. I., Lyakhov, S. A., Firestein, G. S. & Quinn, M. T., 1 Jun 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 3, p. 505-516 12 p.

Research output: Contribution to journalArticle

Experimental Arthritis
JNK Mitogen-Activated Protein Kinases
Anti-Inflammatory Agents
Phosphotransferases
Joints
12 Citations (Scopus)

Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents

Schepetkin, I. A., Kushnarenko, S. V., Özek, G., Kirpotina, L. N., Utegenova, G. A., Kotukhov, Y. A., Danilova, A. N., Özek, T., Başer, K. H. C. & Quinn, M. T., 27 May 2015, In : Journal of Agricultural and Food Chemistry. 63, 20, p. 4999-5007 9 p.

Research output: Contribution to journalArticle

Artemisia
Volatile Oils
Formyl Peptide Receptor
neutrophils
Reactive Oxygen Species
2014
7 Citations (Scopus)

Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2

Lacivita, E., Schepetkin, I. A., Stama, M. L., Kirpotina, L. N., Colabufo, N. A., Perrone, R., Khlebnikov, A. I., Quinn, M. T. & Leopoldo, M., 11 Sep 2014, In : Bioorganic and Medicinal Chemistry. 23, 14, p. 3913-3924 12 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Molecular modeling
G-Protein-Coupled Receptors
Derivatives
human FPR2 protein
2013
21 Citations (Scopus)

3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Leopoldo, M., Lucente, E., Lacivita, E., De Giorgio, P. & Quinn, M. T., 1 Feb 2013, In : Biochemical Pharmacology. 85, 3, p. 404-416 13 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Molecular modeling
Enantiomers
Structure-Activity Relationship
G-Protein-Coupled Receptors
15 Citations (Scopus)

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: Design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists

Giovannoni, M. P., Schepetkin, I. A., Cilibrizzi, A., Crocetti, L., Khlebnikov, A. I., Dahlgren, C., Graziano, A., Dal Piaz, V., Kirpotina, L. N., Zerbinati, S., Vergelli, C. & Quinn, M. T., 2013, In : European Journal of Medicinal Chemistry. 64, p. 512-528 17 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Trp-Lys-Tyr-Met-Val-Met
Bearings (structural)
Fluxes
Lead compounds
36 Citations (Scopus)

Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia

Kouakou, K., Schepetkin, I. A., Yapi, A., Kirpotina, L. N., Jutila, M. A. & Quinn, M. T., 7 Mar 2013, In : Journal of Ethnopharmacology. 146, 1, p. 232-242 11 p.

Research output: Contribution to journalArticle

Euphorbiaceae
Polysaccharides
Molecular Weight
Traditional Medicine
Mitogen-Activated Protein Kinases
20 Citations (Scopus)

Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: Beneficial effects in experimental autoimmune encephalomyelitis

Kouakou, K., Schepetkin, I. A., Jun, S., Kirpotina, L. N., Yapi, A., Khramova, D. S., Pascual, D. W., Ovodov, Y. S., Jutila, M. A. & Quinn, M. T., 28 Jun 2013, In : BMC Complementary and Alternative Medicine. 13, 149.

Research output: Contribution to journalArticle

Clerodendrum
Autoimmune Experimental Encephalomyelitis
Polysaccharides
Macrophage Inflammatory Proteins
Toll-Like Receptor 4
14 Citations (Scopus)

Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum

Schepetkin, I. A., Kouakou, K., Yapi, A., Kirpotina, L. N., Jutila, M. A. & Quinn, M. T., Mar 2013, In : International Immunopharmacology. 15, 3, p. 628-637 10 p.

Research output: Contribution to journalArticle

Combretum
Polysaccharides
Interleukin-6
Blood Cells
Glycogen Synthase Kinase 3
34 Citations (Scopus)

Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase

Crocetti, L., Schepetkin, I. A., Cilibrizzi, A., Graziano, A., Vergelli, C., Giomi, D., Khlebnikov, A. I., Quinn, M. T. & Giovannoni, M. P., 8 Aug 2013, In : Journal of Medicinal Chemistry. 56, 15, p. 6259-6272 14 p.

Research output: Contribution to journalArticle

Secretory Proteinase Inhibitory Proteins
Leukocyte Elastase
Inhibitory Concentration 50
Indazoles
Ligands
6 Citations (Scopus)

Synthesis, HPLC enantioresolution, and X-ray analysis of a new series of C5-methyl pyridazines as N-formyl peptide receptor (FPR) Agonists

Cilibrizzi, A., Crocetti, L., Giovannoni, M. P., Graziano, A., Vergelli, C., Bartolucci, G., Soldani, G., Quinn, M. T., Schepetkin, I. A. & Faggi, C., Jul 2013, In : Chirality. 25, 7, p. 400-408 9 p.

Research output: Contribution to journalArticle

Pyridazines
Formyl Peptide Receptor
X ray analysis
Cellulose
Peptides
11 Citations (Scopus)

Synthesis and pharmacological evaluation of new pyridazin-based thioderivatives as formyl peptide receptor (FPR) agonists

Crocetti, L., Vergelli, C., Cilibrizzi, A., Graziano, A., Khlebnikov, A. I., Kirpotina, L. N., Schepetkin, I. A., Quinn, M. T. & Giovannoni, M. P., Jun 2013, In : Drug Development Research. 74, 4, p. 259-271 13 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Pharmacology
Chemotaxis
Neutrophils
Oxygen Compounds
2012
25 Citations (Scopus)

Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Hanks, T. S., Kochetkova, I., Pascual, D. W., Jutila, M. A. & Quinn, M. T., Jun 2012, In : Molecular Pharmacology. 81, 6, p. 832-845 14 p.

Research output: Contribution to journalArticle

Oximes
JNK Mitogen-Activated Protein Kinases
Interleukin-1
Lipopolysaccharides
Interleukin-6
15 Citations (Scopus)

Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1

Khlebnikov, A. I., Schepetkin, I. A., Kirpotina, L. N., Brive, L., Dahlgren, C., Jutila, M. A. & Quinn, M. T., Jun 2012, In : Journal of Molecular Modeling. 18, 6, p. 2831-2843 13 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Peptides
peptides
Molecules
Ligands
29 Citations (Scopus)

Nasal acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei infections

Skyberg, J. A., Rollins, M. F., Holderness, J. S., Marlenee, N. L., Schepetkin, I. A., Goodyear, A., Dow, S. W., Jutila, M. A. & Pascual, D. W., Mar 2012, In : PLoS Pathogens. 8, 3, e1002587.

Research output: Contribution to journalArticle

Burkholderia Infections
Burkholderia pseudomallei
Francisella tularensis
Nose
Innate Immunity
21 Citations (Scopus)

Oenothein B, a Cyclic Dimeric Ellagitannin Isolated from Epilobium angustifolium, Enhances IFNγ Production by Lymphocytes

Ramstead, A. G., Schepetkin, I. A., Quinn, M. T. & Jutila, M. A., 30 Nov 2012, In : PLoS One. 7, 11, e50546.

Research output: Contribution to journalArticle

Epilobium
Epilobium angustifolium
Lymphocytes
interferons
Interferons
15 Citations (Scopus)

Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists

Cilibrizzi, A., Schepetkin, I. A., Bartolucci, G., Crocetti, L., Dal Piaz, V., Giovannoni, M. P., Graziano, A., Kirpotina, L. N., Quinn, M. T. & Vergelli, C., 15 Jun 2012, In : Bioorganic and Medicinal Chemistry. 20, 12, p. 3781-3792 12 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Enantiomers
Arrestin
CHO Cells
HL-60 Cells
2011
18 Citations (Scopus)

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase

Crocetti, L., Giovannoni, M. P., Schepetkin, I. A., Quinn, M. T., Khlebnikov, A. I., Cilibrizzi, A., Piaz, V. D., Graziano, A. & Vergelli, C., 1 Aug 2011, In : Bioorganic and Medicinal Chemistry. 19, 15, p. 4460-4472 13 p.

Research output: Contribution to journalArticle

Secretory Proteinase Inhibitory Proteins
Leukocyte Elastase
Derivatives
Bioactivity
Scaffolds
17 Citations (Scopus)

Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Jutila, M. A. & Quinn, M. T., Jan 2011, In : Molecular Pharmacology. 79, 1, p. 77-90 14 p.

Research output: Contribution to journalArticle

Bombesin Receptors
Formyl Peptide Receptor
Gastrin-Releasing Peptide
G-Protein-Coupled Receptors
Ligands
44 Citations (Scopus)

Polysaccharides isolated from açaí fruit induce innate immune responses

Holderness, J., Schepetkin, I. A., Freedman, B., Kirpotina, L. N., Quinn, M. T., Hedges, J. F. & Jutila, M. A., 2011, In : PLoS One. 6, 2, e17301.

Research output: Contribution to journalArticle

Fruits
Innate Immunity
Polysaccharides
Fruit
polysaccharides
2010
4 Citations (Scopus)
Formyl Peptide Receptor
Structure-Activity Relationship
Molecules
Cluster analysis
Discriminant Analysis
42 Citations (Scopus)

Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition

Kirpotina, L. N., Khlebnikov, A. I., Schepetkin, I. A., Ye, R. D., Rabiet, M. J., Jutila, M. A. & Quinn, M. T., Feb 2010, In : Molecular Pharmacology. 77, 2, p. 159-170 12 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Calcium
Ligands
Aptitude
HL-60 Cells
7 Citations (Scopus)

Nicotinamide glycolates antagonize CXCR2 activity through an intracellular mechanism

Maeda, D. Y., Quinn, M. T., Schepetkin, I. A., Kirpotina, L. N. & Zebala, J. A., Jan 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 1, p. 145-152 8 p.

Research output: Contribution to journalArticle

Glycolates
glycolic acid
Niacinamide
Neutrophils
Acids
2009
27 Citations (Scopus)

6-Methyl-2,4-disubstituted pyridazin-3(2H)-ones: A novel class of small-molecule agonists for formyl peptide receptors

Cilibrizzi, A., Quinn, M. T., Kirpotina, L. N., Schepetkin, I. A., Holderness, J., Ye, R. D., Rabiet, M. J., Biancalani, C., Cesari, N., Graziano, A., Vergelli, C., Pieretti, S., Dal Piaz, V. & Giovannoni, M. P., 27 Aug 2009, In : Journal of Medicinal Chemistry. 52, 16, p. 5044-5057 14 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Calcium
HL-60 Cells
Drug Design
Chemotaxis
15 Citations (Scopus)

Complement-fixing activity of fulvic acid from Shilajit and other natural sources

Schepetkin, I. A., Xie, G., Jutila, M. A. & Quinn, M. T., Mar 2009, In : Phytotherapy Research. 23, 3, p. 373-384 12 p.

Research output: Contribution to journalArticle

mumie
fulvic acid
Complement Activation
Traditional Medicine
Gel Chromatography
46 Citations (Scopus)

Immunomodulatory activity of oenothein B isolated from Epilobium angustifolium

Schepetkin, I. A., Kirpotina, L. N., Jakiw, L., Khlebnikov, A. I., Blaskovich, C. L., Jutila, M. A. & Quinn, M. T., 15 Nov 2009, In : Journal of Immunology. 183, 10, p. 6754-6766 13 p.

Research output: Contribution to journalArticle

Epilobium
Phagocytes
Hydrolyzable Tannins
Pyrogallol
Gallic Acid