• 2857 Citations
  • 25 h-Index
1991 …2020

Research output per year

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Research Output

  • 2857 Citations
  • 25 h-Index
  • 103 Article
  • 11 Review article
  • 6 Conference contribution
  • 1 Chapter
2012

Nasal acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei infections

Skyberg, J. A., Rollins, M. F., Holderness, J. S., Marlenee, N. L., Schepetkin, I. A., Goodyear, A., Dow, S. W., Jutila, M. A. & Pascual, D. W., Mar 2012, In : PLoS Pathogens. 8, 3, e1002587.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Oenothein B, a Cyclic Dimeric Ellagitannin Isolated from Epilobium angustifolium, Enhances IFNγ Production by Lymphocytes

Ramstead, A. G., Schepetkin, I. A., Quinn, M. T. & Jutila, M. A., 30 Nov 2012, In : PLoS One. 7, 11, e50546.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists

Cilibrizzi, A., Schepetkin, I. A., Bartolucci, G., Crocetti, L., Dal Piaz, V., Giovannoni, M. P., Graziano, A., Kirpotina, L. N., Quinn, M. T. & Vergelli, C., 15 Jun 2012, In : Bioorganic and Medicinal Chemistry. 20, 12, p. 3781-3792 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2011

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase

Crocetti, L., Giovannoni, M. P., Schepetkin, I. A., Quinn, M. T., Khlebnikov, A. I., Cilibrizzi, A., Piaz, V. D., Graziano, A. & Vergelli, C., 1 Aug 2011, In : Bioorganic and Medicinal Chemistry. 19, 15, p. 4460-4472 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Jutila, M. A. & Quinn, M. T., Jan 2011, In : Molecular Pharmacology. 79, 1, p. 77-90 14 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Polysaccharides isolated from açaí fruit induce innate immune responses

Holderness, J., Schepetkin, I. A., Freedman, B., Kirpotina, L. N., Quinn, M. T., Hedges, J. F. & Jutila, M. A., 2011, In : PLoS One. 6, 2, e17301.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2010
4 Citations (Scopus)

Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition

Kirpotina, L. N., Khlebnikov, A. I., Schepetkin, I. A., Ye, R. D., Rabiet, M. J., Jutila, M. A. & Quinn, M. T., Feb 2010, In : Molecular Pharmacology. 77, 2, p. 159-170 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Nicotinamide glycolates antagonize CXCR2 activity through an intracellular mechanism

Maeda, D. Y., Quinn, M. T., Schepetkin, I. A., Kirpotina, L. N. & Zebala, J. A., Jan 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 1, p. 145-152 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2009

6-Methyl-2,4-disubstituted pyridazin-3(2H)-ones: A novel class of small-molecule agonists for formyl peptide receptors

Cilibrizzi, A., Quinn, M. T., Kirpotina, L. N., Schepetkin, I. A., Holderness, J., Ye, R. D., Rabiet, M. J., Biancalani, C., Cesari, N., Graziano, A., Vergelli, C., Pieretti, S., Dal Piaz, V. & Giovannoni, M. P., 27 Aug 2009, In : Journal of Medicinal Chemistry. 52, 16, p. 5044-5057 14 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Complement-fixing activity of fulvic acid from Shilajit and other natural sources

Schepetkin, I. A., Xie, G., Jutila, M. A. & Quinn, M. T., Mar 2009, In : Phytotherapy Research. 23, 3, p. 373-384 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Immunomodulatory activity of oenothein B isolated from Epilobium angustifolium

Schepetkin, I. A., Kirpotina, L. N., Jakiw, L., Khlebnikov, A. I., Blaskovich, C. L., Jutila, M. A. & Quinn, M. T., 15 Nov 2009, In : Journal of Immunology. 183, 10, p. 6754-6766 13 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Polysaccharides derived from Yamoa™ (Funtumia elastica) prime γδ T cells in vitro and enhance innate immune responses in vivo

Graff, J. C., Kimmel, E. M., Freedman, B., Schepetkin, I. A., Holderness, J., Quinn, M. T., Jutila, M. A. & Hedges, J. F., Oct 2009, In : International Immunopharmacology. 9, 11, p. 1313-1322 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Role of NADPH oxidase in formation and function of multinucleated giant cells

Quinn, M. T. & Schepetkin, I. A., Oct 2009, In : Journal of Innate Immunity. 1, 6, p. 509-526 18 p.

Research output: Contribution to journalReview article

39 Citations (Scopus)

Synthesis, characterization and potent superoxide dismutase-like activity of novel bis(pyrazole)-2,2′-bipyridyl mixed ligand copper(ii) complexes

Potapov, A. S., Nudnova, E. A., Domina, G. A., Kirpotina, L. N., Quinn, M. T., Khlebnikov, A. I. & Schepetkin, I. A., 2009, In : Dalton Transactions. 23, p. 4488-4498 11 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2008

Computational structure-activity relationship analysis of non-peptide inducers of macrophage tumor necrosis factor-α production

Khlebnikov, A. I., Schepetkin, I. A., Kirpotina, L. N. & Quinn, M. T., 15 Oct 2008, In : Bioorganic and Medicinal Chemistry. 16, 20, p. 9302-9312 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Fractionation and characterization of biologically-active polysaccharides from Artemisia tripartita

Xie, G., Schepetkin, I. A., Siemsen, D. W., Kirpotina, L. N., Wiley, J. A. & Quinn, M. T., Apr 2008, In : Phytochemistry. 69, 6, p. 1359-1371 13 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor α production

Schepetkin, I. A., Kirpotina, L. N., Tian, J., Khlebnikov, A. I., Ye, R. D. & Quinn, M. T., Aug 2008, In : Molecular Pharmacology. 74, 2, p. 392-402 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Macrophage immunomodulatory activity of polysaccharides isolated from Opuntia polyacantha

Schepetkin, I. A., Xie, G., Kirpotina, L. N., Klein, R. A., Jutila, M. A. & Quinn, M. T., Oct 2008, In : International Immunopharmacology. 8, 10, p. 1455-1466 12 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)
15 Citations (Scopus)
2007

High-throughput screening for small-molecule activators of neutrophils: Identification of novel N-formyl peptide receptor agonists

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I. & Quinn, M. T., Apr 2007, In : Molecular Pharmacology. 71, 4, p. 1061-1074 14 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L.

Xie, G., Schepetkin, I. A. & Quinn, M. T., 15 Dec 2007, In : International Immunopharmacology. 7, 13, p. 1639-1650 12 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems

Khlebnikov, A. I., Schepetkin, I. A., Domina, N. G., Kirpotina, L. N. & Quinn, M. T., 15 Feb 2007, In : Bioorganic and Medicinal Chemistry. 15, 4, p. 1749-1770 22 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase

Schepetkin, I. A., Khlebnikov, A. I. & Quinn, M. T., 20 Oct 2007, In : Journal of Medicinal Chemistry. 50, 20, p. 4928-4938 11 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Neutrophil isolation from nonhuman species.

Siemsen, D. W., Schepetkin, I. A., Kirpotina, L. N., Lei, B. & Quinn, M. T., 2007, In : Methods in Molecular Biology. 412, p. 21-34 14 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2006

Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential

Schepetkin, I. A. & Quinn, M. T., Mar 2006, In : International Immunopharmacology. 6, 3, p. 317-333 17 p.

Research output: Contribution to journalReview article

840 Citations (Scopus)

Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening

Schepetkin, I. A., Khlebnikov, A. I., Kirpotina, L. N. & Quinn, M. T., 24 Aug 2006, In : Journal of Medicinal Chemistry. 49, 17, p. 5232-5244 13 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
10 Citations (Scopus)
2005

Fulvic acid fractions from mumie

Kwon, B. S., Khlebnikov, A. I., Schepetkin, I. A. & Woo, S. B., 2005, 8th Korea-Russia International Symposium on Science and Technology - Proceedings: KORUS 2004. Vol. 3. p. 352-355 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Macrophage immunomodulatory activity of polysaccharides isolated from Juniperus scopolorum

Schepetkin, I. A., Faulkner, C. L., Nelson-Overton, L. K., Wiley, J. A. & Quinn, M. T., Dec 2005, In : International Immunopharmacology. 5, 13-14, p. 1783-1799 17 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)
2004

Activation of macrophages by plant polysaccharides

Shchepetkin, I. A., 2004, In : Antibiotiki i Khimioterapiya. 49, 1, p. 35-42 8 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2003

Characterization and biological activities of humic substances from mumie

Schepetkin, I. A., Khlebnikov, A. I., Ah, S. Y., Woo, S. B., Jeong, C. S., Klubachuk, O. N. & Kwon, B. S., 27 Aug 2003, In : Journal of Agricultural and Food Chemistry. 51, 18, p. 5245-5254 10 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity

Chernov, M., Schepetkin, I., Ah, S. Y., Khlebnikov, A. I., Klubachuk, O. & Kwon, B. S., 2003, Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology: 7th Korea-Russia International Symposium on Science and Technology. Institute of Electrical and Electronics Engineers Inc., Vol. 4. p. 18-21 4 p. 1222885

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sanazole and metronidazole effect on reactive oxygen species production by macrophages

Shchepetkin, I. A., Cherdyntseva, N. V. & Kagiya, V. T., 2003, In : Antibiotiki i Khimioterapiya. 48, 3, p. 7-10 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2002

Different metabolic effects of ganglioside GM1 in brain synaptosomes and phagocytic cells

Avrova, N. F., Zakharova, I. O., Tyurin, V. A., Tyurina, Y. Y., Gamaley, I. A. & Schepetkin, I. A., Aug 2002, In : Neurochemical Research. 27, 7-8, p. 751-759 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Medical drugs from humus matter: Focus on mumie

Schepetkin, I., Khlebnikov, A. I. & Kwon, B. S., 1 Nov 2002, In : Drug Development Research. 57, 3, p. 140-159 20 p.

Research output: Contribution to journalReview article

67 Citations (Scopus)
8 Citations (Scopus)

Mumie constituents and their biological activity: Modulation of reactive oxygen species (ROS) production of macrophages

Schepetkin, I. A., Klubachuk, O. N., Khlebnikov, A. I. & Kwon, B. S., 2002, Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002. Institute of Electrical and Electronics Engineers Inc., p. 486-489 4 p. 1028071

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Osteoblastic differentiation of mesenchymal stem cells by mumie extract

Jung, C. R., Schepetkin, I. A., Woo, S. B., Khlebnikov, A. I. & Kwon, B. S., 1 Nov 2002, In : Drug Development Research. 57, 3, p. 122-133 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2001

Geometricheskaia model' spiral'no-tsiklicheskoi samoorganizatsii morfofunktsional'nykh blokov s dvumernymi (2D) kanalami perenosa.

Translated title of the contribution: Geometrical model of spiral-cyclical self-organization of morphofunctional modules with two-dimensional (2D) transfer channelsShchepetkin, I. A. & Sergeev, M. A., May 2001, In : Zhurnal Obshchei Biologii. 62, 3, p. 246-252 7 p.

Research output: Contribution to journalArticle

Macrophagal polykaryocytes in inflammation, tumor growth, and tissue remodeling

Schepetkin, I. A., Igor, A., Kiran, K. R. & Kwon, B. S., 2001, In : Journal of Microbiology and Biotechnology. 11, 5, p. 727-738 12 p.

Research output: Contribution to journalReview article

Platinum derivative effect on activity of microsomal NADPH-oxidoreductases

Shchepetkin, I. A., Plotnikov, V. M. & Kagiya, V. T., 2001, In : Voprosy Meditsinskoj Khimii. 47, 4, p. 380-381 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Quantitative Structure-activity Relationships (QSAR) for antitumor activity of nitroazoles: A comparative analysis for the parent compounds and their nitroanione radical and nitrosoanione radical derivatives

Khlebnikov, A. I., Schepetkin, I., Kim, B. S. & Kwon, B. S., 2001, 5th Korea-Russia International Symposium on Science and Technology - Proceedings: KORUS 2001: KORUS 2001. Institute of Electrical and Electronics Engineers Inc., Vol. 3. p. 10-14 5 p. 975012

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Quantitative Structure-Activity Relationships (QSAR) for antitumor activity of nitroazoles: A comparative analysis for the parent compounds and their nitro anione radical and nitroso anione radical derivatives

Khlebnikov, A. I., Schepetkin, I., Kim, B. S. & Kwon, B. S., 2001, 5th Korea-Russia International Symposium on Science and Technology - Proceedings: KORUS 2001: KORUS 2001. Institute of Electrical and Electronics Engineers Inc., Vol. 2. p. 58-62 5 p. 975177

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sanazole as substrate of xanthine oxidase and microsomal NADPH/cytochrome P450 reductase

Schepetkin, I. A., Cherdyntseva, N. V. & Kagiya, V. T., 2001, In : Pathophysiology. 8, 2, p. 119-127 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Vliianie proizvodnykh platiny na aktivnost' mikrosomnykh NADPH-oksidoreduktaz.

Translated title of the contribution: Effect of platinum derivatives on microsomal NADPH-oxidoreductase activityShchepetkin, I. A., Plotnikov, V. M. & Kagiia, V. T., Jul 2001, In : Voprosy Meditsinskoj Khimii. 47, 4, p. 373-381 9 p.

Research output: Contribution to journalArticle

2000

Free radical mechanisms of nitrofurans biological action

Shchepetkin, I. A., 2000, In : Antibiotiki i Khimioterapiya. 45, 8, p. 31-35 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Macrophagal Polykaryons

Schepetkin, I. A., 2000, In : Uspekhi Fiziologicheskikh Nauk. 31, 2, p. 28-34 7 p.

Research output: Contribution to journalArticle