• 2857 Citations
  • 25 h-Index
1991 …2020

Research output per year

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Research Output

  • 2857 Citations
  • 25 h-Index
  • 103 Article
  • 11 Review article
  • 6 Conference contribution
  • 1 Chapter
Article

1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors

Crocetti, L., Giovannoni, M. P., Schepetkin, I. A., Quinn, M. T., Khlebnikov, A. I., Cantini, N., Guerrini, G., Iacovone, A., Teodori, E. & Vergelli, C., 15 Nov 2018, In : Bioorganic and Medicinal Chemistry. 26, 21, p. 5583-5595 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists

Vergelli, C., Schepetkin, I. A., Ciciani, G., Cilibrizzi, A., Crocetti, L., Giovannoni, M. P., Guerrini, G., Iacovone, A., Kirpotina, L. N., Khlebnikov, A. I., Ye, R. D. & Quinn, M. T., 1 Jun 2016, In : Bioorganic and Medicinal Chemistry. 24, 11, p. 2530-2543 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Leopoldo, M., Lucente, E., Lacivita, E., De Giorgio, P. & Quinn, M. T., 1 Feb 2013, In : Biochemical Pharmacology. 85, 3, p. 404-416 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones as N-formyl peptide receptor 1 (FPR1) antagonists

Kirpotina, L. N., Schepetkin, I. A., Khlebnikov, A. I., Ruban, O. I., Ge, Y., Ye, R. D., Kominsky, D. J. & Quinn, M. T., 2017, (Accepted/In press) In : Biochemical Pharmacology. 142, p. 120-132 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

6-Methyl-2,4-disubstituted pyridazin-3(2H)-ones: A novel class of small-molecule agonists for formyl peptide receptors

Cilibrizzi, A., Quinn, M. T., Kirpotina, L. N., Schepetkin, I. A., Holderness, J., Ye, R. D., Rabiet, M. J., Biancalani, C., Cesari, N., Graziano, A., Vergelli, C., Pieretti, S., Dal Piaz, V. & Giovannoni, M. P., 27 Aug 2009, In : Journal of Medicinal Chemistry. 52, 16, p. 5044-5057 14 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B

Ramstead, A. G., Schepetkin, I. A., Todd, K., Loeffelholz, J., Berardinelli, J. G., Quinn, M. T. & Jutila, M. A., 1 Jun 2015, In : International Immunopharmacology. 26, 2, p. 367-377 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice

Atochin, D. N., Shchepetkin, I. A., Khlebnikov, A. I., Seledtsov, V. I., Swanson, H., Quinn, M. T. & Huang, P. L., 8 Apr 2016, In : Neuroscience Letters. 618, p. 45-49 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives

Schepetkin, I. A., Khlebnikov, A. I., Kirpotina, L. N. & Quinn, M. T., 1 Aug 2016, In : International Immunopharmacology. 37, p. 43-58 16 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats

Plotnikov, M. B., Aliev, O. I., Shamanaev, A. Y., Sidekhmenova, A. V., Anishchenko, A. M., Fomina, T. I., Rydchenko, V. S., Khlebnikov, A. I., Anfinogenova, Y. J., Schepetkin, I. A. & Atochin, D. N., 1 Oct 2020, In : Hypertension Research. 43, 10, p. 1068-1078 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Anti-inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun n-terminal kinase inhibitor

Schepetkin, I. A., Kirpotina, L. N., Hammaker, D., Kochetkova, I., Khlebnikov, A. I., Lyakhov, S. A., Firestein, G. S. & Quinn, M. T., 1 Jun 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 3, p. 505-516 12 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Blood neutrophil granulocytes oxidative metabolism in patients with gastric precancer and cancer

Cherdyntseva, N. V., Naumov, S. A., Udut, V. V., Peshkova, O. A. & Shchepetkin, I. A., 1992, In : Voprosy Onkologii. 38, 1-3, p. 182-187 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Characterization and biological activities of humic substances from mumie

Schepetkin, I. A., Khlebnikov, A. I., Ah, S. Y., Woo, S. B., Jeong, C. S., Klubachuk, O. N. & Kwon, B. S., 27 Aug 2003, In : Journal of Agricultural and Food Chemistry. 51, 18, p. 5245-5254 10 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Chemical composition and immunomodulatory activity of hypericum perforatum essential oils

Schepetkin, I. A., Ozek, G., Ozek, T., Kirpotina, L. N., Khlebnikov, A. I. & Quinn, M. T., Jun 2020, In : Biomolecules. 10, 6, p. 1-20 20 p., 916.

Research output: Contribution to journalArticle

Open Access

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Özek, G., Schepetkin, I. A., Utegenova, G. A., Kirpotina, L. N., Andrei, S. R., Özek, T., Başer, K. H. C., Abidkulova, K. T., Kushnarenko, S. V., Khlebnikov, A. I., Damron, D. S. & Quinn, M. T., 1 Jun 2017, In : Journal of Leukocyte Biology. 101, 6, p. 1361-1371 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Cinnoline derivatives as human neutrophil elastase inhibitors

Giovannoni, M. P., Schepetkin, I. A., Crocetti, L., Ciciani, G., Cilibrizzi, A., Guerrini, G., Khlebnikov, A. I., Quinn, M. T. & Vergelli, C., 3 Jul 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 4, p. 628-639 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

c-Jun N-Terminal Kinases and Their Pharmacological Modulation in Ischemic and Reperfusion Brain Injury

Shvedova, M. V., Anfinogenova, Y. D., Shchepetkin, I. A. & Atochin, D. N., 1 Jul 2018, In : Neuroscience and Behavioral Physiology. 48, 6, p. 721-728 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Complement-fixing activity of fulvic acid from Shilajit and other natural sources

Schepetkin, I. A., Xie, G., Jutila, M. A. & Quinn, M. T., Mar 2009, In : Phytotherapy Research. 23, 3, p. 373-384 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Computational structure-activity relationship analysis of non-peptide inducers of macrophage tumor necrosis factor-α production

Khlebnikov, A. I., Schepetkin, I. A., Kirpotina, L. N. & Quinn, M. T., 15 Oct 2008, In : Bioorganic and Medicinal Chemistry. 16, 20, p. 9302-9312 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
4 Citations (Scopus)

Decreased luminol-dependent chemiluminescence response of neutrophils to recombinant human tumour necrosis factor in patients with gastric cancer

Schepetkin, I. A., Cherdyntseva, N. V., Borunov, E. V., Skutina, I. L. & Naumov, S. A., Mar 1991, In : Journal of Cancer Research and Clinical Oncology. 117, 2, p. 172-174 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase

Crocetti, L., Giovannoni, M. P., Schepetkin, I. A., Quinn, M. T., Khlebnikov, A. I., Cilibrizzi, A., Piaz, V. D., Graziano, A. & Vergelli, C., 1 Aug 2011, In : Bioorganic and Medicinal Chemistry. 19, 15, p. 4460-4472 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Different metabolic effects of ganglioside GM1 in brain synaptosomes and phagocytic cells

Avrova, N. F., Zakharova, I. O., Tyurin, V. A., Tyurina, Y. Y., Gamaley, I. A. & Schepetkin, I. A., Aug 2002, In : Neurochemical Research. 27, 7-8, p. 751-759 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
1 Citation (Scopus)

Fractionation and characterization of biologically-active polysaccharides from Artemisia tripartita

Xie, G., Schepetkin, I. A., Siemsen, D. W., Kirpotina, L. N., Wiley, J. A. & Quinn, M. T., Apr 2008, In : Phytochemistry. 69, 6, p. 1359-1371 13 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Free radical mechanisms of nitrofurans biological action

Shchepetkin, I. A., 2000, In : Antibiotiki i Khimioterapiya. 45, 8, p. 31-35 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase

Giovannoni, M. P., Cantini, N., Crocetti, L., Guerrini, G., Iacovone, A., Schepetkin, I. A., Vergelli, C., Khlebnikov, A. I. & Quinn, M. T., 1 Jan 2019, In : Drug Development Research.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: Design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists

Giovannoni, M. P., Schepetkin, I. A., Cilibrizzi, A., Crocetti, L., Khlebnikov, A. I., Dahlgren, C., Graziano, A., Dal Piaz, V., Kirpotina, L. N., Zerbinati, S., Vergelli, C. & Quinn, M. T., 2013, In : European Journal of Medicinal Chemistry. 64, p. 512-528 17 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Jutila, M. A. & Quinn, M. T., Jan 2011, In : Molecular Pharmacology. 79, 1, p. 77-90 14 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Geometricheskaia model' spiral'no-tsiklicheskoi samoorganizatsii morfofunktsional'nykh blokov s dvumernymi (2D) kanalami perenosa.

Translated title of the contribution: Geometrical model of spiral-cyclical self-organization of morphofunctional modules with two-dimensional (2D) transfer channelsShchepetkin, I. A. & Sergeev, M. A., May 2001, In : Zhurnal Obshchei Biologii. 62, 3, p. 246-252 7 p.

Research output: Contribution to journalArticle

High-throughput screening for small-molecule activators of neutrophils: Identification of novel N-formyl peptide receptor agonists

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I. & Quinn, M. T., Apr 2007, In : Molecular Pharmacology. 71, 4, p. 1061-1074 14 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Hanks, T. S., Kochetkova, I., Pascual, D. W., Jutila, M. A. & Quinn, M. T., Jun 2012, In : Molecular Pharmacology. 81, 6, p. 832-845 14 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor α production

Schepetkin, I. A., Kirpotina, L. N., Tian, J., Khlebnikov, A. I., Ye, R. D. & Quinn, M. T., Aug 2008, In : Molecular Pharmacology. 74, 2, p. 392-402 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition

Kirpotina, L. N., Khlebnikov, A. I., Schepetkin, I. A., Ye, R. D., Rabiet, M. J., Jutila, M. A. & Quinn, M. T., Feb 2010, In : Molecular Pharmacology. 77, 2, p. 159-170 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L.

Xie, G., Schepetkin, I. A. & Quinn, M. T., 15 Dec 2007, In : International Immunopharmacology. 7, 13, p. 1639-1650 12 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Immunomodulatory activity of oenothein B isolated from Epilobium angustifolium

Schepetkin, I. A., Kirpotina, L. N., Jakiw, L., Khlebnikov, A. I., Blaskovich, C. L., Jutila, M. A. & Quinn, M. T., 15 Nov 2009, In : Journal of Immunology. 183, 10, p. 6754-6766 13 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia

Kouakou, K., Schepetkin, I. A., Yapi, A., Kirpotina, L. N., Jutila, M. A. & Quinn, M. T., 7 Mar 2013, In : Journal of Ethnopharmacology. 146, 1, p. 232-242 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: Beneficial effects in experimental autoimmune encephalomyelitis

Kouakou, K., Schepetkin, I. A., Jun, S., Kirpotina, L. N., Yapi, A., Khramova, D. S., Pascual, D. W., Ovodov, Y. S., Jutila, M. A. & Quinn, M. T., 28 Jun 2013, In : BMC Complementary and Alternative Medicine. 13, 149.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum

Schepetkin, I. A., Kouakou, K., Yapi, A., Kirpotina, L. N., Jutila, M. A. & Quinn, M. T., Mar 2013, In : International Immunopharmacology. 15, 3, p. 628-637 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems

Khlebnikov, A. I., Schepetkin, I. A., Domina, N. G., Kirpotina, L. N. & Quinn, M. T., 15 Feb 2007, In : Bioorganic and Medicinal Chemistry. 15, 4, p. 1749-1770 22 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)
3 Citations (Scopus)

Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents

Schepetkin, I. A., Kushnarenko, S. V., Özek, G., Kirpotina, L. N., Utegenova, G. A., Kotukhov, Y. A., Danilova, A. N., Özek, T., Başer, K. H. C. & Quinn, M. T., 27 May 2015, In : Journal of Agricultural and Food Chemistry. 63, 20, p. 4999-5007 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70

Khlebnikov, A. I., Schepetkin, I. A., Kishkentaeva, A. S., Shaimerdenova, Z. R., Atazhanova, G. A., Adekenov, S. M., Kirpotina, L. N. & Quinn, M. T., 19 Jan 2019, In : Molecules (Basel, Switzerland). 24, 2

Research output: Contribution to journalArticle

1 Citation (Scopus)

Inhibitory effect of IQ-1S, a selective c-Jun N-terminal kinase (JNK) inhibitor, on phenotypical and cytokine-producing characteristics in human macrophages and T-cells

Seledtsov, V. I., Malashchenko, V. V., Meniailo, M. E., Atochin, D. N., Seledtsova, G. V. & Schepetkin, I. A., 5 Jul 2020, In : European Journal of Pharmacology. 878, 173116.

Research output: Contribution to journalArticle

Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors

Vergelli, C., Schepetkin, I. A., Crocetti, L., Iacovone, A., Giovannoni, M. P., Guerrini, G., Khlebnikov, A. I., Ciattini, S., Ciciani, G. & Quinn, M. T., 1 Jan 2017, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 32, 1, p. 821-831 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Khemiliuminestsentsiia neǐtrofilov s ispol'zovaniem pribora "Luminometer-1251" i programmy "Lumograf".

Translated title of the contribution: Neutrophil chemiluminescence using the Luminometer-1251 device and the Lumograf programBorunov, E. V., Shchepetkin, I. A., Cherdyntsev, E. S. & Cherdyntseva, N. V., Jul 1993, In : Klinicheskaia laboratornaia diagnostika. 4, p. 13-16 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Lucigenin as a Substrate of Microsomal NAD(P)H-Oxidoreductases

Schepetkin, I. A., Jan 1999, In : Biochemistry (Moscow). 64, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Lucigenin as a substrate of microsomal NAD(P)H-oxidoreductases.

Schepetkin, I. A., Jan 1999, In : Biochemistry. Biokhimiia. 64, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Lucigenin luminescence elicited by microsomes and its modulation by nitroazole compounds

Schepetkin, I. A., 1999, In : IUBMB Life. 48, 5, p. 499-504 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)