• 2719 Citations
  • 24 h-Index
1991 …2020

Research output per year

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Research Output

  • 2719 Citations
  • 24 h-Index
  • 98 Article
  • 11 Review article
  • 6 Conference contribution
  • 1 Chapter
2020

Chemical composition and immunomodulatory activity of hypericum perforatum essential oils

Schepetkin, I. A., Ozek, G., Ozek, T., Kirpotina, L. N., Khlebnikov, A. I. & Quinn, M. T., Jun 2020, In : Biomolecules. 10, 6, p. 1-20 20 p., 916.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Inhibitory effect of IQ-1S, a selective c-Jun N-terminal kinase (JNK) inhibitor, on phenotypical and cytokine-producing characteristics in human macrophages and T-cells

Seledtsov, V. I., Malashchenko, V. V., Meniailo, M. E., Atochin, D. N., Seledtsova, G. V. & Schepetkin, I. A., 5 Jul 2020, In : European Journal of Pharmacology. 878, 173116.

Research output: Contribution to journalArticle

2019

Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase

Giovannoni, M. P., Cantini, N., Crocetti, L., Guerrini, G., Iacovone, A., Schepetkin, I. A., Vergelli, C., Khlebnikov, A. I. & Quinn, M. T., 1 Jan 2019, In : Drug Development Research.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70

Khlebnikov, A. I., Schepetkin, I. A., Kishkentaeva, A. S., Shaimerdenova, Z. R., Atazhanova, G. A., Adekenov, S. M., Kirpotina, L. N. & Quinn, M. T., 19 Jan 2019, In : Molecules (Basel, Switzerland). 24, 2

Research output: Contribution to journalArticle

1 Citation (Scopus)

Neutrophil immunomodulatory activity of natural organosulfur compounds

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Balasubramanian, N. & Quinn, M. T., 1 Jan 2019, In : Molecules. 24, 9, 1809.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Poly(ϵ-caprolactone) Scaffolds Doped with c-Jun N-terminal Kinase Inhibitors Modulate Phagocyte Activation

Stankevich, K. S., Schepetkin, I. A., Goreninskii, S. I., Lavrinenko, A. K., Bolbasov, E. N., Kovrizhina, A. R., Kirpotina, L. N., Filimonov, V. D., Khlebnikov, A. I., Tverdokhlebov, S. I. & Quinn, M. T., 11 Nov 2019, In : ACS Biomaterials Science and Engineering. 5, 11, p. 5990-5999 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats

Plotnikov, M. B., Chernysheva, G. A., Aliev, O. I., Smol'iakova, V. I., Fomina, T. I., Osipenko, A. N., Rydchenko, V. S., Anfinogenova, Y. J., Khlebnikov, A. I., Schepetkin, I. A. & Atochin, D. N., 1 Jan 2019, In : Molecules. 24, 9, 1722.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25

Schepetkin, I. A., Karpenko, A. S., Khlebnikov, A. I., Shibinska, M. O., Levandovskiy, I. A., Kirpotina, L. N., Danilenko, N. V. & Quinn, M. T., 1 Dec 2019, In : European Journal of Medicinal Chemistry. 183, 111719.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors

Schepetkin, I. A., Khlebnikov, A. I., Potapov, A. S., Kovrizhina, A. R., Matveevskaya, V. V., Belyanin, M. L., Atochin, D. N., Zanoza, S. O., Gaidarzhy, N. M., Lyakhov, S. A., Kirpotina, L. N. & Quinn, M. T., 1 Jan 2019, In : European Journal of Medicinal Chemistry. 161, p. 179-191 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Synthesis, Structure, and Anti-Inflammatory Activity of Functionally Substituted Chalcones and Their Derivatives

Nurkenov, O. A., Ibraev, M. K., Schepetkin, I. A., Khlebnikov, A. I., Seilkhanov, T. M., Arinova, A. E. & Isabaeva, M. B., 1 Jul 2019, In : Russian Journal of General Chemistry. 89, 7, p. 1360-1367 8 p.

Research output: Contribution to journalArticle

2018

1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors

Crocetti, L., Giovannoni, M. P., Schepetkin, I. A., Quinn, M. T., Khlebnikov, A. I., Cantini, N., Guerrini, G., Iacovone, A., Teodori, E. & Vergelli, C., 15 Nov 2018, In : Bioorganic and Medicinal Chemistry. 26, 21, p. 5583-5595 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

c-Jun N-terminal kinases (JNKs) in myocardial and cerebral ischemia/reperfusion injury

Shvedova, M., Anfinogenova, Y., Atochina-Vasserman, E. N., Schepetkin, I. A. & Atochin, D. N., 5 Jul 2018, In : Frontiers in Pharmacology. 9, JUL, 715.

Research output: Contribution to journalReview article

22 Citations (Scopus)
1 Citation (Scopus)

Physicochemical characterization and antioxidant activity of humic acids isolated from peat of various origins

Zykova, M. V., Schepetkin, I. A., Belousov, M. V., Krivoshchekov, S. V., Logvinova, L. A., Bratishko, K. A., Yusubov, M. S., Romanenko, S. V. & Quinn, M. T., 1 Jan 2018, In : Molecules. 23, 4, 753.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
2017

4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones as N-formyl peptide receptor 1 (FPR1) antagonists

Kirpotina, L. N., Schepetkin, I. A., Khlebnikov, A. I., Ruban, O. I., Ge, Y., Ye, R. D., Kominsky, D. J. & Quinn, M. T., 2017, (Accepted/In press) In : Biochemical Pharmacology. 142, p. 120-132 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Özek, G., Schepetkin, I. A., Utegenova, G. A., Kirpotina, L. N., Andrei, S. R., Özek, T., Başer, K. H. C., Abidkulova, K. T., Kushnarenko, S. V., Khlebnikov, A. I., Damron, D. S. & Quinn, M. T., 1 Jun 2017, In : Journal of Leukocyte Biology. 101, 6, p. 1361-1371 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors

Vergelli, C., Schepetkin, I. A., Crocetti, L., Iacovone, A., Giovannoni, M. P., Guerrini, G., Khlebnikov, A. I., Ciattini, S., Ciciani, G. & Quinn, M. T., 1 Jan 2017, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 32, 1, p. 821-831 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide

Nurkenov, O. A., Satpaeva, Z. B., Schepetkin, I. A., Khlebnikov, A. I., Turdybekov, K. M., Seilkhanov, T. M. & Fazylov, S. D., 1 Oct 2017, In : Russian Journal of General Chemistry. 87, 10, p. 2299-2306 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Synthesis of new hydrazones based on o- and p-hydroxybenzohydrazides

Nurkenov, O. A., Satpaeva, Z. B., Shchepetkin, I. A., Fazylov, S. D., Seilkhanov, T. M. & Akhmetova, S. B., 1 Aug 2017, In : Russian Journal of General Chemistry. 87, 8, p. 1707-1710 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists

Vergelli, C., Schepetkin, I. A., Ciciani, G., Cilibrizzi, A., Crocetti, L., Giovannoni, M. P., Guerrini, G., Iacovone, A., Kirpotina, L. N., Khlebnikov, A. I., Ye, R. D. & Quinn, M. T., 1 Jun 2016, In : Bioorganic and Medicinal Chemistry. 24, 11, p. 2530-2543 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice

Atochin, D. N., Shchepetkin, I. A., Khlebnikov, A. I., Seledtsov, V. I., Swanson, H., Quinn, M. T. & Huang, P. L., 8 Apr 2016, In : Neuroscience Letters. 618, p. 45-49 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives

Schepetkin, I. A., Khlebnikov, A. I., Kirpotina, L. N. & Quinn, M. T., 1 Aug 2016, In : International Immunopharmacology. 37, p. 43-58 16 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Cinnoline derivatives as human neutrophil elastase inhibitors

Giovannoni, M. P., Schepetkin, I. A., Crocetti, L., Ciciani, G., Cilibrizzi, A., Guerrini, G., Khlebnikov, A. I., Quinn, M. T. & Vergelli, C., 3 Jul 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 4, p. 628-639 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents

Schepetkin, I. A., Kushnarenko, S. V., Özek, G., Kirpotina, L. N., Sinharoy, P., Utegenova, G. A., Abidkulova, K. T., Özek, T., Başer, K. H. C., Kovrizhina, A. R., Khlebnikov, A. I., Damron, D. S. & Quinn, M. T., 28 Sep 2016, In : Journal of Agricultural and Food Chemistry. 64, 38, p. 7156-7170 15 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Synthesis and Cytotoxicity of bis(pyrazol-1-yl)-Alkane Derivatives with Polymethylene Linkers and Related Mono- and Dipyrazolium Salts

Zatonskaya, L. V., Schepetkin, I. A., Petrenko, T. V., Ogorodnikov, V. D., Khlebnikov, A. I. & Potapov, A. S., 1 Jun 2016, In : Chemistry of Heterocyclic Compounds. 52, 6, p. 388-401 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis and Pharmacological Evaluation of Indole Derivatives as Deaza Analogues of Potent Human Neutrophil Elastase Inhibitors

Crocetti, L., Schepetkin, I. A., Ciciani, G., Giovannoni, M. P., Guerrini, G., Iacovone, A., Khlebnikov, A. I., Kirpotina, L. N., Quinn, M. T. & Vergelli, C., 2016, (Accepted/In press) In : Drug Development Research.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed)

Schepetkin, I. A., Ramstead, A. G., Kirpotina, L. N., Voyich, J. M., Jutila, M. A. & Quinn, M. T., 2016, (Accepted/In press) In : Phytotherapy Research.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015

Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B

Ramstead, A. G., Schepetkin, I. A., Todd, K., Loeffelholz, J., Berardinelli, J. G., Quinn, M. T. & Jutila, M. A., 1 Jun 2015, In : International Immunopharmacology. 26, 2, p. 367-377 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Anti-inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun n-terminal kinase inhibitor

Schepetkin, I. A., Kirpotina, L. N., Hammaker, D., Kochetkova, I., Khlebnikov, A. I., Lyakhov, S. A., Firestein, G. S. & Quinn, M. T., 1 Jun 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 3, p. 505-516 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents

Schepetkin, I. A., Kushnarenko, S. V., Özek, G., Kirpotina, L. N., Utegenova, G. A., Kotukhov, Y. A., Danilova, A. N., Özek, T., Başer, K. H. C. & Quinn, M. T., 27 May 2015, In : Journal of Agricultural and Food Chemistry. 63, 20, p. 4999-5007 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014

Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Cheng, N., Ye, R. D. & Quinn, M. T., 15 Dec 2014, In : Biochemical Pharmacology. 92, 4, p. 627-641 15 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition

Schepetkin, I. A., Khlebnikov, A. I., Giovannoni, M. P., Kirpotina, L. N., Cilibrizzi, A. & Quinn, M. T., 2014, In : Current Medicinal Chemistry. 21, 13, p. 1478-1504 27 p.

Research output: Contribution to journalReview article

26 Citations (Scopus)

Neutrophil isolation from nonhuman species

Siemsen, D. W., Malachowa, N., Schepetkin, I. A., Whitney, A. R., Kirpotina, L. N., Lei, B., Deleo, F. R. & Quinn, M. T., 2014, Neutrophil Methods and Protocols. Humana Press Inc., Vol. 1124. p. 19-37 19 p. (Methods in Molecular Biology; vol. 1124).

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Citations (Scopus)

Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2

Lacivita, E., Schepetkin, I. A., Stama, M. L., Kirpotina, L. N., Colabufo, N. A., Perrone, R., Khlebnikov, A. I., Quinn, M. T. & Leopoldo, M., 11 Sep 2014, In : Bioorganic and Medicinal Chemistry. 23, 14, p. 3913-3924 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2013

3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Leopoldo, M., Lucente, E., Lacivita, E., De Giorgio, P. & Quinn, M. T., 1 Feb 2013, In : Biochemical Pharmacology. 85, 3, p. 404-416 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: Design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists

Giovannoni, M. P., Schepetkin, I. A., Cilibrizzi, A., Crocetti, L., Khlebnikov, A. I., Dahlgren, C., Graziano, A., Dal Piaz, V., Kirpotina, L. N., Zerbinati, S., Vergelli, C. & Quinn, M. T., 2013, In : European Journal of Medicinal Chemistry. 64, p. 512-528 17 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia

Kouakou, K., Schepetkin, I. A., Yapi, A., Kirpotina, L. N., Jutila, M. A. & Quinn, M. T., 7 Mar 2013, In : Journal of Ethnopharmacology. 146, 1, p. 232-242 11 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: Beneficial effects in experimental autoimmune encephalomyelitis

Kouakou, K., Schepetkin, I. A., Jun, S., Kirpotina, L. N., Yapi, A., Khramova, D. S., Pascual, D. W., Ovodov, Y. S., Jutila, M. A. & Quinn, M. T., 28 Jun 2013, In : BMC Complementary and Alternative Medicine. 13, 149.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum

Schepetkin, I. A., Kouakou, K., Yapi, A., Kirpotina, L. N., Jutila, M. A. & Quinn, M. T., Mar 2013, In : International Immunopharmacology. 15, 3, p. 628-637 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase

Crocetti, L., Schepetkin, I. A., Cilibrizzi, A., Graziano, A., Vergelli, C., Giomi, D., Khlebnikov, A. I., Quinn, M. T. & Giovannoni, M. P., 8 Aug 2013, In : Journal of Medicinal Chemistry. 56, 15, p. 6259-6272 14 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Synthesis, HPLC enantioresolution, and X-ray analysis of a new series of C5-methyl pyridazines as N-formyl peptide receptor (FPR) Agonists

Cilibrizzi, A., Crocetti, L., Giovannoni, M. P., Graziano, A., Vergelli, C., Bartolucci, G., Soldani, G., Quinn, M. T., Schepetkin, I. A. & Faggi, C., Jul 2013, In : Chirality. 25, 7, p. 400-408 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis and pharmacological evaluation of new pyridazin-based thioderivatives as formyl peptide receptor (FPR) agonists

Crocetti, L., Vergelli, C., Cilibrizzi, A., Graziano, A., Khlebnikov, A. I., Kirpotina, L. N., Schepetkin, I. A., Quinn, M. T. & Giovannoni, M. P., Jun 2013, In : Drug Development Research. 74, 4, p. 259-271 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2012

Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Hanks, T. S., Kochetkova, I., Pascual, D. W., Jutila, M. A. & Quinn, M. T., Jun 2012, In : Molecular Pharmacology. 81, 6, p. 832-845 14 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1

Khlebnikov, A. I., Schepetkin, I. A., Kirpotina, L. N., Brive, L., Dahlgren, C., Jutila, M. A. & Quinn, M. T., Jun 2012, In : Journal of Molecular Modeling. 18, 6, p. 2831-2843 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Nasal acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei infections

Skyberg, J. A., Rollins, M. F., Holderness, J. S., Marlenee, N. L., Schepetkin, I. A., Goodyear, A., Dow, S. W., Jutila, M. A. & Pascual, D. W., Mar 2012, In : PLoS Pathogens. 8, 3, e1002587.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Oenothein B, a Cyclic Dimeric Ellagitannin Isolated from Epilobium angustifolium, Enhances IFNγ Production by Lymphocytes

Ramstead, A. G., Schepetkin, I. A., Quinn, M. T. & Jutila, M. A., 30 Nov 2012, In : PLoS One. 7, 11, e50546.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists

Cilibrizzi, A., Schepetkin, I. A., Bartolucci, G., Crocetti, L., Dal Piaz, V., Giovannoni, M. P., Graziano, A., Kirpotina, L. N., Quinn, M. T. & Vergelli, C., 15 Jun 2012, In : Bioorganic and Medicinal Chemistry. 20, 12, p. 3781-3792 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2011

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase

Crocetti, L., Giovannoni, M. P., Schepetkin, I. A., Quinn, M. T., Khlebnikov, A. I., Cilibrizzi, A., Piaz, V. D., Graziano, A. & Vergelli, C., 1 Aug 2011, In : Bioorganic and Medicinal Chemistry. 19, 15, p. 4460-4472 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)