• 1225 Citations
  • 21 h-Index
1986 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1225 Citations
  • 21 h-Index
  • 76 Article
  • 5 Conference contribution
  • 4 Review article
  • 1 Comment/debate
Filter
Article
2020

Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats

Plotnikov, M. B., Aliev, O. I., Shamanaev, A. Y., Sidekhmenova, A. V., Anishchenko, A. M., Fomina, T. I., Rydchenko, V. S., Khlebnikov, A. I., Anfinogenova, Y. J., Schepetkin, I. A. & Atochin, D. N., 1 Oct 2020, In : Hypertension Research. 43, 10, p. 1068-1078 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Chemical composition and immunomodulatory activity of hypericum perforatum essential oils

Schepetkin, I. A., Ozek, G., Ozek, T., Kirpotina, L. N., Khlebnikov, A. I. & Quinn, M. T., Jun 2020, In : Biomolecules. 10, 6, p. 1-20 20 p., 916.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia

Plotnikov, M. B., Chernysheva, G. A., Smolyakova, V. I., Aliev, O. I., Trofimova, E. S., Sherstoboev, E. Y., Osipenko, A. N., Khlebnikov, A. I., Anfinogenova, Y. J., Schepetkin, I. A. & Atochin, D. N., 8 Aug 2020, In : Cells. 9, 8

Research output: Contribution to journalArticle

Open Access

Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors

Crocetti, L., Giovannoni, M. P., Cantini, N., Guerrini, G., Vergelli, C., Schepetkin, I. A., Khlebnikov, A. I. & Quinn, M. T., 1 Sep 2020, In : Frontiers in Chemistry. 8, 795.

Research output: Contribution to journalArticle

Open Access

The investigation of structure–activity relationship of polyamine-targeted synthetic compounds from different chemical groups

Syatkin, S. P., Neborak, E. V., Khlebnikov, A. I., Komarova, M. V., Shevkun, N. A., Kravtsov, E. G., Blagonravov, M. L. & Agostinelli, E., 1 Feb 2020, In : Amino Acids. 52, 2, p. 199-211 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Therapeutic Effects of Tryptanthrin and Tryptanthrin-6-Oxime in Models of Rheumatoid Arthritis

Kirpotina, L. N., Schepetkin, I. A., Hammaker, D., Kuhs, A., Khlebnikov, A. I. & Quinn, M. T., 24 Jul 2020, In : Frontiers in Pharmacology. 11, 1145.

Research output: Contribution to journalArticle

Open Access
2019

Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase

Giovannoni, M. P., Cantini, N., Crocetti, L., Guerrini, G., Iacovone, A., Schepetkin, I. A., Vergelli, C., Khlebnikov, A. I. & Quinn, M. T., 1 Jan 2019, In : Drug Development Research.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70

Khlebnikov, A. I., Schepetkin, I. A., Kishkentaeva, A. S., Shaimerdenova, Z. R., Atazhanova, G. A., Adekenov, S. M., Kirpotina, L. N. & Quinn, M. T., 19 Jan 2019, In : Molecules (Basel, Switzerland). 24, 2

Research output: Contribution to journalArticle

1 Citation (Scopus)

Neutrophil immunomodulatory activity of natural organosulfur compounds

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Balasubramanian, N. & Quinn, M. T., 1 Jan 2019, In : Molecules. 24, 9, 1809.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Poly(ϵ-caprolactone) Scaffolds Doped with c-Jun N-terminal Kinase Inhibitors Modulate Phagocyte Activation

Stankevich, K. S., Schepetkin, I. A., Goreninskii, S. I., Lavrinenko, A. K., Bolbasov, E. N., Kovrizhina, A. R., Kirpotina, L. N., Filimonov, V. D., Khlebnikov, A. I., Tverdokhlebov, S. I. & Quinn, M. T., 11 Nov 2019, In : ACS Biomaterials Science and Engineering. 5, 11, p. 5990-5999 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats

Plotnikov, M. B., Chernysheva, G. A., Aliev, O. I., Smol'iakova, V. I., Fomina, T. I., Osipenko, A. N., Rydchenko, V. S., Anfinogenova, Y. J., Khlebnikov, A. I., Schepetkin, I. A. & Atochin, D. N., 1 Jan 2019, In : Molecules. 24, 9, 1722.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25

Schepetkin, I. A., Karpenko, A. S., Khlebnikov, A. I., Shibinska, M. O., Levandovskiy, I. A., Kirpotina, L. N., Danilenko, N. V. & Quinn, M. T., 1 Dec 2019, In : European Journal of Medicinal Chemistry. 183, 111719.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors

Schepetkin, I. A., Khlebnikov, A. I., Potapov, A. S., Kovrizhina, A. R., Matveevskaya, V. V., Belyanin, M. L., Atochin, D. N., Zanoza, S. O., Gaidarzhy, N. M., Lyakhov, S. A., Kirpotina, L. N. & Quinn, M. T., 1 Jan 2019, In : European Journal of Medicinal Chemistry. 161, p. 179-191 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Synthesis, Structure, and Anti-Inflammatory Activity of Functionally Substituted Chalcones and Their Derivatives

Nurkenov, O. A., Ibraev, M. K., Schepetkin, I. A., Khlebnikov, A. I., Seilkhanov, T. M., Arinova, A. E. & Isabaeva, M. B., 1 Jul 2019, In : Russian Journal of General Chemistry. 89, 7, p. 1360-1367 8 p.

Research output: Contribution to journalArticle

2018

1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors

Crocetti, L., Giovannoni, M. P., Schepetkin, I. A., Quinn, M. T., Khlebnikov, A. I., Cantini, N., Guerrini, G., Iacovone, A., Teodori, E. & Vergelli, C., 15 Nov 2018, In : Bioorganic and Medicinal Chemistry. 26, 21, p. 5583-5595 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones as N-formyl peptide receptor 1 (FPR1) antagonists

Kirpotina, L. N., Schepetkin, I. A., Khlebnikov, A. I., Ruban, O. I., Ge, Y., Ye, R. D., Kominsky, D. J. & Quinn, M. T., 2017, (Accepted/In press) In : Biochemical Pharmacology. 142, p. 120-132 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Özek, G., Schepetkin, I. A., Utegenova, G. A., Kirpotina, L. N., Andrei, S. R., Özek, T., Başer, K. H. C., Abidkulova, K. T., Kushnarenko, S. V., Khlebnikov, A. I., Damron, D. S. & Quinn, M. T., 1 Jun 2017, In : Journal of Leukocyte Biology. 101, 6, p. 1361-1371 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors

Vergelli, C., Schepetkin, I. A., Crocetti, L., Iacovone, A., Giovannoni, M. P., Guerrini, G., Khlebnikov, A. I., Ciattini, S., Ciciani, G. & Quinn, M. T., 1 Jan 2017, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 32, 1, p. 821-831 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide

Nurkenov, O. A., Satpaeva, Z. B., Schepetkin, I. A., Khlebnikov, A. I., Turdybekov, K. M., Seilkhanov, T. M. & Fazylov, S. D., 1 Oct 2017, In : Russian Journal of General Chemistry. 87, 10, p. 2299-2306 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists

Vergelli, C., Schepetkin, I. A., Ciciani, G., Cilibrizzi, A., Crocetti, L., Giovannoni, M. P., Guerrini, G., Iacovone, A., Kirpotina, L. N., Khlebnikov, A. I., Ye, R. D. & Quinn, M. T., 1 Jun 2016, In : Bioorganic and Medicinal Chemistry. 24, 11, p. 2530-2543 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice

Atochin, D. N., Shchepetkin, I. A., Khlebnikov, A. I., Seledtsov, V. I., Swanson, H., Quinn, M. T. & Huang, P. L., 8 Apr 2016, In : Neuroscience Letters. 618, p. 45-49 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives

Schepetkin, I. A., Khlebnikov, A. I., Kirpotina, L. N. & Quinn, M. T., 1 Aug 2016, In : International Immunopharmacology. 37, p. 43-58 16 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Cinnoline derivatives as human neutrophil elastase inhibitors

Giovannoni, M. P., Schepetkin, I. A., Crocetti, L., Ciciani, G., Cilibrizzi, A., Guerrini, G., Khlebnikov, A. I., Quinn, M. T. & Vergelli, C., 3 Jul 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 4, p. 628-639 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Mild reaction of primary alcohols with ferulic acid

Bakholdina, L. A., Khlebnikov, A. I. & Sevodin, V. P., 1 Mar 2016, In : Russian Journal of Organic Chemistry. 52, 3, p. 441-443 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents

Schepetkin, I. A., Kushnarenko, S. V., Özek, G., Kirpotina, L. N., Sinharoy, P., Utegenova, G. A., Abidkulova, K. T., Özek, T., Başer, K. H. C., Kovrizhina, A. R., Khlebnikov, A. I., Damron, D. S. & Quinn, M. T., 28 Sep 2016, In : Journal of Agricultural and Food Chemistry. 64, 38, p. 7156-7170 15 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Synthesis and Cytotoxicity of bis(pyrazol-1-yl)-Alkane Derivatives with Polymethylene Linkers and Related Mono- and Dipyrazolium Salts

Zatonskaya, L. V., Schepetkin, I. A., Petrenko, T. V., Ogorodnikov, V. D., Khlebnikov, A. I. & Potapov, A. S., 1 Jun 2016, In : Chemistry of Heterocyclic Compounds. 52, 6, p. 388-401 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Synthesis and Pharmacological Evaluation of Indole Derivatives as Deaza Analogues of Potent Human Neutrophil Elastase Inhibitors

Crocetti, L., Schepetkin, I. A., Ciciani, G., Giovannoni, M. P., Guerrini, G., Iacovone, A., Khlebnikov, A. I., Kirpotina, L. N., Quinn, M. T. & Vergelli, C., 2016, (Accepted/In press) In : Drug Development Research.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Synthesis and structural characterization of copper(II) coordination polymers with 1,1,2,2-tetra(pyrazol-1-yl)ethane

Semitut, E. Y., Komarov, V. Y., Filatov, E. Y., Kuznetsova, A. S., Khlebnikov, A. I. & Potapov, A. S., 1 Feb 2016, In : Inorganic Chemistry Communications. 64, p. 23-26 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

Anti-inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun n-terminal kinase inhibitor

Schepetkin, I. A., Kirpotina, L. N., Hammaker, D., Kochetkova, I., Khlebnikov, A. I., Lyakhov, S. A., Firestein, G. S. & Quinn, M. T., 1 Jun 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 3, p. 505-516 12 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
20 Citations (Scopus)
2014

Facile synthesis of pyrazole- and benzotriazole-containing selenoethers

Potapov, A. S., Chernova, N. P., Ogorodnikov, V. D., Petrenko, T. V. & Khlebnikov, A. I., 2014, In : Scientific World Journal. 2014, 578762.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2

Lacivita, E., Schepetkin, I. A., Stama, M. L., Kirpotina, L. N., Colabufo, N. A., Perrone, R., Khlebnikov, A. I., Quinn, M. T. & Leopoldo, M., 11 Sep 2014, In : Bioorganic and Medicinal Chemistry. 23, 14, p. 3913-3924 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2013

3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Leopoldo, M., Lucente, E., Lacivita, E., De Giorgio, P. & Quinn, M. T., 1 Feb 2013, In : Biochemical Pharmacology. 85, 3, p. 404-416 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: Design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists

Giovannoni, M. P., Schepetkin, I. A., Cilibrizzi, A., Crocetti, L., Khlebnikov, A. I., Dahlgren, C., Graziano, A., Dal Piaz, V., Kirpotina, L. N., Zerbinati, S., Vergelli, C. & Quinn, M. T., 2013, In : European Journal of Medicinal Chemistry. 64, p. 512-528 17 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase

Crocetti, L., Schepetkin, I. A., Cilibrizzi, A., Graziano, A., Vergelli, C., Giomi, D., Khlebnikov, A. I., Quinn, M. T. & Giovannoni, M. P., 8 Aug 2013, In : Journal of Medicinal Chemistry. 56, 15, p. 6259-6272 14 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Synthesis and pharmacological evaluation of new pyridazin-based thioderivatives as formyl peptide receptor (FPR) agonists

Crocetti, L., Vergelli, C., Cilibrizzi, A., Graziano, A., Khlebnikov, A. I., Kirpotina, L. N., Schepetkin, I. A., Quinn, M. T. & Giovannoni, M. P., Jun 2013, In : Drug Development Research. 74, 4, p. 259-271 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2012

Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Hanks, T. S., Kochetkova, I., Pascual, D. W., Jutila, M. A. & Quinn, M. T., Jun 2012, In : Molecular Pharmacology. 81, 6, p. 832-845 14 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1

Khlebnikov, A. I., Schepetkin, I. A., Kirpotina, L. N., Brive, L., Dahlgren, C., Jutila, M. A. & Quinn, M. T., Jun 2012, In : Journal of Molecular Modeling. 18, 6, p. 2831-2843 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2011

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase

Crocetti, L., Giovannoni, M. P., Schepetkin, I. A., Quinn, M. T., Khlebnikov, A. I., Cilibrizzi, A., Piaz, V. D., Graziano, A. & Vergelli, C., 1 Aug 2011, In : Bioorganic and Medicinal Chemistry. 19, 15, p. 4460-4472 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I., Jutila, M. A. & Quinn, M. T., Jan 2011, In : Molecular Pharmacology. 79, 1, p. 77-90 14 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2010
4 Citations (Scopus)

Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition

Kirpotina, L. N., Khlebnikov, A. I., Schepetkin, I. A., Ye, R. D., Rabiet, M. J., Jutila, M. A. & Quinn, M. T., Feb 2010, In : Molecular Pharmacology. 77, 2, p. 159-170 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2009

Immunomodulatory activity of oenothein B isolated from Epilobium angustifolium

Schepetkin, I. A., Kirpotina, L. N., Jakiw, L., Khlebnikov, A. I., Blaskovich, C. L., Jutila, M. A. & Quinn, M. T., 15 Nov 2009, In : Journal of Immunology. 183, 10, p. 6754-6766 13 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Synthesis, characterization and potent superoxide dismutase-like activity of novel bis(pyrazole)-2,2′-bipyridyl mixed ligand copper(ii) complexes

Potapov, A. S., Nudnova, E. A., Domina, G. A., Kirpotina, L. N., Quinn, M. T., Khlebnikov, A. I. & Schepetkin, I. A., 2009, In : Dalton Transactions. 23, p. 4488-4498 11 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2008

Computational structure-activity relationship analysis of non-peptide inducers of macrophage tumor necrosis factor-α production

Khlebnikov, A. I., Schepetkin, I. A., Kirpotina, L. N. & Quinn, M. T., 15 Oct 2008, In : Bioorganic and Medicinal Chemistry. 16, 20, p. 9302-9312 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor α production

Schepetkin, I. A., Kirpotina, L. N., Tian, J., Khlebnikov, A. I., Ye, R. D. & Quinn, M. T., Aug 2008, In : Molecular Pharmacology. 74, 2, p. 392-402 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
15 Citations (Scopus)
2007

High-throughput screening for small-molecule activators of neutrophils: Identification of novel N-formyl peptide receptor agonists

Schepetkin, I. A., Kirpotina, L. N., Khlebnikov, A. I. & Quinn, M. T., Apr 2007, In : Molecular Pharmacology. 71, 4, p. 1061-1074 14 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems

Khlebnikov, A. I., Schepetkin, I. A., Domina, N. G., Kirpotina, L. N. & Quinn, M. T., 15 Feb 2007, In : Bioorganic and Medicinal Chemistry. 15, 4, p. 1749-1770 22 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)